Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

Caputi, Lorenzo; Franke, Jakob; C. Farrow, Scott; Chung, Khoa; Payne, Richard; Nguyen, Trinh‐Don; T. Dang, Thu‐Thuy; Carqueijeiro, Inês; Koudounas, Konstantinos; Dugé de Bernonville, Thomas; Ameyaw, Belinda; Marc Jones, D.; José Curcino Vieira, Ivo; Courdavault, Vincent; E. O’Connor, Sarah

doi:10.1126/science.aat4100

Public

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

Published in Science • May 3, 2018

Authors:

Lorenzo Caputi

Jakob Franke

Scott C. Farrow

Abstract

(Madagascar periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis could provide an additional source of this drug. However, the chemistry underlying vinblastine synthesis makes identification of the biosynthetic genes challenging. Here we identify the two missi...

Subject

Vindoline

Vinblastine

Catharanthus roseus

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