Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1

Zhou, Lixing; Zhang, Mingming; Wang, Yuming; Dorfman, Robert; Liu, Hang; Yu, Ting; Chen, Xiaotian; Tang, Dehua; Xu, Lei; Yin, Yuyao; Pan, Yida; Zhou, Qian; Zhou, Yihua; Yu, Chenggong

doi:10.1093/ibd/izy182

Public

Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1

Published in Inflammatory Bowel Diseases • May 23, 2018

Authors:

Lixing Zhou

Mingming Zhang

Yuming Wang

Abstract

BACKGROUND: Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD...

Subject

Faecalibacterium prausnitzii

Butyrate

Medicine

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