Quantitative mass imaging of single biological macromolecules

Young, Gavin; Hundt, Nikolas; Cole, Daniel; Fineberg, Adam; Andrecka, Joanna; Tyler, Andrew; Olerinyova, Anna; Ansari, Ayla; G. Marklund, Erik; P. Collier, Miranda; A. Chandler, Shane; Tkachenko, Olga; Allen, Joel; Crispin, Max; Billington, Neil; Takagi, Yasuharu; R. Sellers, James; Eichmann, Cédric; Selenko, Philipp; Frey, Lukas; Riek, Roland; R. Galpin, Martin; B. Struwe, Weston; L. P. Benesch, Justin; Kukura, Philipp

doi:10.1126/science.aar5839

Public

Quantitative mass imaging of single biological macromolecules

Shared by NobleBlocks on Apr 27, 2018 • 12:00 AM UTC

Authors:

Gavin Young

Nikolas Hundt

Daniel Cole

Abstract

Watching proteins' weight Careful measurements of light scattering can provide information on individual macromolecules and complexes. Young et al. used a light-scattering approach for accurate mass determination of proteins as small as 20 kDa (see the Perspective by Lee and Klenerman). Movies of pr...

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