The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Ann Pereira, Natasha; Fai Chan, Kah; Chun Lin, Pao; Song, Zhiwei

doi:10.1080/19420862.2018.1466767

Public

The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Published in mAbs • May 7, 2018

Authors:

Natasha Ann Pereira

Kah Fai Chan

Pao Chun Lin

Abstract

Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy, some IgG1 antibodies rely on the Fc-mediated immune effector function, antibody-dependent cellular cytotoxicity (ADCC),...

Subject

Antibody-dependent cell-mediated cytotoxicity

Fucosylation

Antibody

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!