Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Cheul Oh, Sang; Hwa Sohn, Bo; Cheong, Jae‐Ho; Kim, Sang-Bae; Eun Lee, Jae; Eun Lee, Jae; Cheong Park, Ki; Ho Lee, Sang; Park, Yun-Yong; Park, Yun-Yong; Lee, Hyun‐Sung; Jang, Hee-Jin; Sung Park, Eun; Kim, Sang-Cheol; Heo, Jeonghoon; Chu, In‐Sun; Jang, You-Jin; Mok, Young‐Jae; Jung, Wonkyung; Kim, Aeree; Kim, Aeree; Yong Cho, Jae; Yun Lim, Jae; Hayashi, Yuki; Song, Shumei; Elimova, Elena; S. Estralla, Jeannelyn; H. Lee, Jeffrey; H. Lee, Jeffrey; S. Bhutani, Manoop; Lu, Yiling; Liu, Wenbin; Lee, Jeeyun; Lee, Jeeyun; Ki Kang, Won; Kim, Seon‐Young; Hoon Noh, Sung; B. Mills, Gordon; Kim, Seon‐Young; A. Ajani, Jaffer; Lee, Ju‐Seog; Lee, Ju‐Seog

doi:10.1038/s41467-018-04179-8

Public

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Published in Nature Communications • Apr 27, 2018

Authors:

Sang Cheul Oh

Bo Hwa Sohn

Jae‐Ho Cheong

Abstract

Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomi...

Subject

Phenotype

Insulin-like growth factor 1 receptor

Cancer

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