Expression of scavenger receptor <scp>MARCO</scp> defines a targetable tumor‐associated macrophage subset in non‐small cell lung cancer

La Fleur, Linnéa; F. Boura, Vanessa; Alexeyenko, Andrey; Berglund, Anders; Pontén, Victor; Sofia Margareta Mattsson, Johanna; Djureinovic, Dijana; Persson, Johan; Brunnström, Hans; Isaksson, Johan; Brandén, Eva; Koyi, Hirsh; Micke, Patrick; C. I. Karlsson, Mikael; Botling, Johan

doi:10.1002/ijc.31545

Public

Expression of scavenger receptor MARCO defines a targetable tumor‐associated macrophage subset in non‐small cell lung cancer

Published in International Journal of Cancer • Apr 18, 2018

Authors:

Linnéa La Fleur

Vanessa F. Boura

Andrey Alexeyenko

Abstract

Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated th...

Subject

CD163

Immune system

Immunotherapy

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