Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer.

Fleur L, La; VF, Boura; A, Alexeyenko; A, Berglund; V, Pontén; JSM, Mattsson; D, Djureinovic; J, Persson; H, Brunnström; J, Isaksson; E, Brandén; H, Koyi; P, Micke; MCI, Karlsson; J, Botling

doi:10.1002/ijc.31545

Public

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer.

Shared by NobleBlocks on May 13, 2018 • 12:00 AM UTC

Authors:

La Fleur L

Boura VF

Alexeyenko A

Abstract

Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated th...

Subject

Lung cancer

PD-L1

immune therapy

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