Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Zhang, Jing; Yu, Chunbo; Zhang, Xuan; Chen, Huiwen; Dong, Jiachen; Lu, Weili; Song, Zhongchen; Zhou, Wei

doi:10.1186/s12974-017-1052-x

Public

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Published in Journal of Neuroinflammation • Feb 9, 2018

Authors:

Jing Zhang

Chunbo Yu

Xuan Zhang

Abstract

BACKGROUND: Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS) is one of the major pathogenic factors of chronic periodontitis (CP). Few reports on the correlation between P. gingivalis-LPS and cognitive function exist. Thus, the present study aimed to investigate the effects of P. ging...

Subject

Porphyromonas gingivalis

Morris water navigation task

TLR4

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