Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP

Yang, Yaxiong; Liu, Nan; He, Yuanyuan; Liu, Yuxia; Ge, Lin; Zou, Linzhi; Song, Sen; Xiong, Wei; Liu, Xiaodong

doi:10.1038/s41467-018-03719-6

Public

Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP

Published in Nature Communications • Apr 11, 2018

Authors:

Yaxiong Yang

Nan Liu

Yuanyuan He

Abstract

Abstract GCaMP, one popular type of genetically-encoded Ca 2+ indicator, has been associated with various side-effects. Here we unveil the intrinsic problem prevailing over different versions and applications, showing that GCaMP containing CaM (calmodulin) interferes with both gating and signaling o...

Subject

Calmodulin

Cell biology

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