FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

Qamar, Seema; Wang, Guo-Zhen; J. Randle, Suzanne; Simone Ruggeri, Francesco; A. Varela, Juan; Qiaojin Lin, Julie; Claire Phillips, Emma; Miyashita, Akinori; Williams, Declan; Ströhl, Florian; Meadows, William; Rose Ferry, Rodylyn; Dardov, Victoria; Gaetano Tartaglia, Gian; A. Farrer, Lindsay; S. Kaminski Schierle, Gabriele; F. Kaminski, Clemens; E. Holt, Christine; E. Fraser, Paul; Schmitt‐Ulms, Gerold; Klenerman, David; P. J. Knowles, Tuomas; Vendruscolo, Michele; St George‐Hyslop, Peter

doi:10.1016/j.cell.2018.03.056

Public

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

Published in Cell • Apr 1, 2018

Authors:

Seema Qamar

Guo-Zhen Wang

Suzanne J. Randle

Abstract

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the LC domain ...

Subject

Biology

Methylation

Arginine

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