Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

Campbell, Bruce; Mitchell, Peter; Churilov, Leonid; Yassi, Nawaf; Kleinig, Timothy; Dowling, Richard; Yan, Bernard; Bush, Steven; M. Dewey, Helen; Thijs, Vincent; Scroop, Rebecca; Simpson, Marion; Brooks, Mark; Asadi, Hamed; Y. Wu, Teddy; Shah, Darshan; Wijeratne, Tissa; Ang, Timothy; Miteff, Ferdinand; Levi, Christopher; Rodrigues, Edrich; Zhao, Henry; Salvaris, Patrick; García-Esperón, Carlos; Bailey, Peter; E. Rice, Henry; de Villiers, Laetitia; Brown, Helen; Redmond, Kendal; Leggett, David; Fink, John; Collecutt, Wayne; Wong, Andrew; Muller, Claire; Coulthard, Alan; Mitchell, Ken; Clouston, John; Mahady, Kate; Field, Deborah; Ma, Henry; G. Phan, Thanh; Chong, Winston; V. Chandra, Ronil; Slater, Lee‐Anne; Krause, Martín; Harrington, Timothy; Faulder, Kenneth; Steinfort, Brendan; F. Bladin, Christopher; Sharma, Gagan; Desmond, Patricia; Parsons, Mark; A. Donnan, Geoffrey; M. Davis, Stephen

doi:10.1056/nejmoa1716405

Public

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

Published in New England Journal of Medicine • Apr 25, 2018

Authors:

Bruce Campbell

Peter Mitchell

Leonid Churilov

Abstract

BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer activity than alteplase, is given as a bolus and may increase the incidence of vascular reperfusion. METHODS: We ran...

Subject

Medicine

Tenecteplase

Modified Rankin Scale

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