X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs

Pasque, Vincent; Karnik, Rahul; Chronis, Constantinos; E. Petrella, Paula; Langerman, Justin; Bonora, Giancarlo; Song, Juan; Vanheer, Lotte; Dimashkie, Anupama; Meissner, Alexander; Plath, Kathrin

doi:10.1016/j.stemcr.2018.03.019

Public

X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs

Published in Stem Cell Reports • Apr 19, 2018

Authors:

Vincent Pasque

Rahul Karnik

Constantinos Chronis

Abstract

A dramatic difference in global DNA methylation between male and female cells characterizes mouse embryonic stem cells (ESCs), unlike somatic cells. We analyzed DNA methylation changes during reprogramming of male and female somatic cells and in resulting induced pluripotent stem cells (iPSCs). At a...

Subject

Reprogramming

Biology

DNA methylation

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