A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review

Sha, Yanwei; Zheng, Liangkai; Ji, Zhiyong; Mei, Libin; Ding, Lu; Lin, Shaobin; Wang, Xu; Yang, Xiaoyu; Li, Ping

doi:10.1186/s12881-018-0570-4

Public

A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review

Published in BMC Medical Genetics • Apr 16, 2018

Authors:

Yanwei Sha

Liangkai Zheng

Zhiyong Ji

Abstract

BACKGROUND: Testis-expressed gene 11 (TEX11) is an X-linked gene and essential for meiotic recombination and chromosomal synapsis. TEX11 deficiency causes meiotic arrest and male infertility, and many TEX11 mutations have been found in azoospermic and infertile men. CASE PRESENTATION: This study rep...

Subject

Azoospermia

Missense mutation

Male infertility

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