Sex, amyloid, and <i>APOE</i> ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

F. Buckley, Rachel; C. Mormino, Elizabeth; E. Amariglio, Rebecca; J Properzi, Michael; S. Rabin, Jennifer; Ying Lim, Yen; V. Papp, Kathryn; I.L. Jacobs, Heidi; C. Burnham, Samantha; Hanseeuw, Bernard; Doré, Vincent; J. Dobson, Annette; L. Masters, Colin; Waller, Michael; C. Rowe, Christopher; Maruff, Paul; Donohue, Michael; M. Rentz, Dorene; Kirn, Dylan; Hedden, Trey; P. Chhatwal, Jasmeer; P. Schultz, Aaron; A. Johnson, Keith; L. Villemagne, Victor; A. Sperling, Reisa; behalf of collaborators in the Alzheimer's Disease Neuroimaging Initiative, on; Australian Imaging, Biomarker and Lifestyle study of ageing, the; Harvard Aging Brain Study, the

doi:10.1016/j.jalz.2018.04.010

Public

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

Published in Alzheimer s & Dementia • May 24, 2018

Authors:

Rachel F. Buckley

Elizabeth C. Mormino

Rebecca E. Amariglio

Abstract

INTRODUCTION: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. METHODS: We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzhei...

Subject

Cognitive decline

Apolipoprotein E

Dementia

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