Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

Yao, Chunxia; Veleva, Tina; Scott, Larry; Cao, Shuyi; Li, Luge; Chen, Gong; Jeyabal, Prince; Pan, Xiaolu; M. Alsina, Katherina; Abu-Taha, Issam; Ghezelbash, Shokoufeh; Reynolds, Corey; H. Shen, Ying; A. LeMaire, Scott; Schmitz, Wilhelm; U. Müller, Frank; El‐Armouche, Ali; Tony Eissa, N.; Beeton, Christine; Nattel, Stanley; H.T. Wehrens, Xander; Dobrev, Dobromir; Li, Na

doi:10.1161/circulationaha.118.035202

Public

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

Published in Circulation • May 25, 2018

Authors:

Chunxia Yao

Tina Veleva

Larry Scott

Abstract

Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome mediates caspase-1 activation and interleukin-1β release in immune cells but is not known to play a role in cardiomyocytes (CMs)...

Subject

Medicine

Inflammasome

Atrial fibrillation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!