<i>NRG1</i> Fusions in <i>KRAS</i> Wild-Type Pancreatic Cancer.

C, Heining; P, Horak; S, Uhrig; PL, Codo; B, Klink; B, Hutter; M, Fröhlich; D, Bonekamp; D, Richter; K, Steiger; R, Penzel; V, Endris; KR, Ehrenberg; S, Frank; K, Kleinheinz; UH, Toprak; M, Schlesner; R, Mandal; L, Schulz; H, Lambertz; S, Fetscher; M, Bitzer; NP, Malek; M, Horger; NA, Giese; O, Strobel; T, Hackert; C, Springfeld; L, Feuerbach; F, Bergmann; E, Schröck; Kalle C, von; W, Weichert; C, Scholl; CR, Ball; A, Stenzinger; B, Brors; S, Fröhling; H, Glimm

doi:10.1158/2159-8290.cd-18-0036

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NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer.

Shared by NobleBlocks on May 25, 2018 • 12:00 AM UTC

Authors:

Heining C

Horak P

Uhrig S

Abstract

We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 patients with PDAC enrolled in a precision oncology program revealed gene fusions amenable to pharmac...

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