Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Tang, Zhibing; Zhao, Lin; Yang, Zaixing; Liu, Zhaohui; Gu, Jia; Bai, Bing; Liu, Jinlian; Xu, Jiaying; Yang, Huilin

doi:10.2147/ijn.s159388

Public

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Published in International Journal of Nanomedicine • May 1, 2018

Authors:

Zhibing Tang

Lin Zhao

Zaixing Yang

Abstract

Background: Graphene and its derivative graphene oxide (GO) have been implicated in a wide range of anticancer effects. Purpose: The objective of this study was to systematically evaluate the toxicity and underlying mechanisms of GO on two osteosarcoma (OSA) cancer cell lines, MG-63 and K 7 M 2 cell...

Subject

Apoptosis

Reactive oxygen species

Oxidative stress

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