STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Hsu, Jung-Mao; Xia, Weiya; Elsa Hsu, Yi‐Hsin; Chan, Li-Chuan; Yu, Wen-Hsuan; Cha, Jong‐Ho; Chen, Chun‐Te; Liao, Hsin-Wei; Kuo, Chu‐Wei; Khoo, Kay‐Hooi; L. Hsu, Jennifer; Li, Chia-Wei; Lim, Seung-Oe; Chang, Shih-Shin; Chen, Yi‐Chun; Ren, Guo-xin; Hung, Mien‐Chie

doi:10.1038/s41467-018-04313-6

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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Published in Nature Communications • May 9, 2018

Authors:

Jung-Mao Hsu

Weiya Xia

Yi‐Hsin Elsa Hsu

Abstract

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial-mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 signaling...

Subject

Cancer stem cell

Epithelial–mesenchymal transition

Cancer research

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