IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

L. Mallery, Donna; L. Márquez, Chantal; A. McEwan, William; F. Dickson, Claire; A. Jacques, David; Anandapadamanaban, Madhanagopal; Bichel, Katsiaryna; J. Towers, Greg; Saiardi, Adolfo; Böcking, Till; C. James, Leo

doi:10.7554/elife.35335

Public

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

Published in eLife • May 31, 2018

Authors:

Donna L. Mallery

Chantal L. Márquez

William A. McEwan

Abstract

The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulate ...

Subject

Capsid

DNA

Biophysics

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