First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury

Kucher, Klaus; R. Johns, Donald; Maier, Doris; Abel, Rainer; Badke, Andreas; Baron, Hagen; Thietje, Roland; Casha, Steven; Ch. Meindl, Renate; Gomez‐Mancilla, Baltazar; Pfister, C.; Rupp, Rüdiger; Weidner, Norbert; K. Mir, Anis; E. Schwab, Martin; Curt, Armin

doi:10.1177/1545968318776371

Public

First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury

Published in Neurorehabilitation and neural repair • Jun 1, 2018

Authors:

Klaus Kucher

Donald R. Johns

Doris Maier

Abstract

BACKGROUND: Neutralization of central nervous system neurite growth inhibitory factors, for example, Nogo-A, is a promising approach to improving recovery following spinal cord injury (SCI). In animal SCI models, intrathecal delivery of anti-Nogo-A antibodies promoted regenerative neurite growth and...

Subject

Medicine

Tetraplegia

Spinal cord injury

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