Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

Schmitt, H; Billmeier, Ulrike; Dieterich, Walburga; Räth, Timo; Sonnewald, Sophia; Reid, Stephen; Hirschmann, Simon; Hildner, Kai; J. Waldner, Maximilian; Mudter, Jonas; Hartmann, Arndt; Grützmann, Robert; Neufert, Clemens; Münster, Tino; F. Neurath, Markus; Atreya, Raja

doi:10.1136/gutjnl-2017-315671

Public

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

Published in Gut • May 30, 2018

Authors:

H Schmitt

Ulrike Billmeier

Walburga Dieterich

Abstract

OBJECTIVE: Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn's disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF ther...

Subject

Tumor necrosis factor alpha

Medicine

Apoptosis

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