Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

A. Sparano, Joseph; J. Gray, Robert; Makower, Della; I. Pritchard, Kathleen; S. Albain, Kathy; F. Hayes, Daniel; E. Geyer, Charles; Claire Dees, Elizabeth; P. Goetz, Matthew; A. Olson, John; Lively, Tracy; Badve, Sunil; J. Saphner, Thomas; I. Wagner, Lynne; J. Whelan, Timothy; J. Ellis, Matthew; Paik, Soonmyung; C. Wood, William; M. Ravdin, Peter; Keane, Maccon; Gómez, Henry; S. Reddy, Pavan; F. Goggins, Timothy; A. Mayer, Ingrid; Brufsky, Adam; Toppmeyer, Deborah; Kaklamani, Virginia; L. Berenberg, Jeffrey; S. Abrams, Jeffrey; W. Sledge, George

doi:10.1056/nejmoa1804710

Public

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

Published in New England Journal of Medicine • Jun 3, 2018

Authors:

Joseph A. Sparano

Robert J. Gray

Della Makower

Abstract

BACKGROUND: The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it is low; however, there is uncertainty about the benefit of chemotherapy for most patients, who have a midrange score...

Subject

Adjuvant

Breast cancer

Adjuvant chemotherapy

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