Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Alonso, Ruby; Flament, Héloïse; Lemoine, Sébastien; Sedlik, Christine; Bottasso, Emanuel; Péguillet, Isabel; Prémel, Virginie; Denizeau, Jordan; Salou, Marion; Darbois, Aurélie; Gonzalo Núñez, Nicolás; L. Salomon, Benoı̂t; Gross, David‐Alexandre; Piaggio, Eliane; Lantz, Olivier

doi:10.1038/s41467-018-04524-x

Public

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Published in Nature Communications • May 23, 2018

Authors:

Ruby Alonso

Héloïse Flament

Sébastien Lemoine

Abstract

Abstract CD4+T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human cancers are not secreted. The fate of Ag-specific CD4+T cells recognizing a cytoplasmic Ag in mice bearing autochthonous tumors is st...

Subject

Lymph node

Tumor cells

Cancer research

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