Heteromeric GABAA receptor structures in positively-modulated active states

P., Miller,; S., Masiulis,; T., Malinauskas,; A., Kotecha,; S., Rao,; S., Chavali,; Colibus, L., De; E., Pardon,; S., Hannan,; S., Scott,; Z., Sun,; B., Frenz,; G., Klesse,; S., Li,; J., Diprose,; A., Siebert,; R., Esnouf,; F., DiMaio,; S., Tucker,; T., Smart,; J., Steyaert,; M., Babu,; M., Sansom,; J., Huiskonen,; R., Aricescu,

doi:10.1101/338343

Public

Heteromeric GABAA receptor structures in positively-modulated active states

Shared by NobleBlocks on Jun 4, 2018 • 12:00 AM UTC

Authors:

Miller, P.

Masiulis, S.

Malinauskas, T.

Abstract

Type-A {gamma}-aminobutyric acid (GABAA) receptors are pentameric ligand-gated ion channels (pLGICs), typically consisting of /{beta}/{gamma} subunit combinations. They are the principal mediators of inhibitory neurotransmission throughout the central nervous system and targets of major clinical dru...

Subject

biophysics

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