Heteromeric GABA <sub>A</sub> receptor structures in positively-modulated active states

S. Miller, Paul; Masiulis, Simonas; Malinauskas, Tomas; Kotecha, Abhay; Rao, Shanlin; Chavali, Sreenivas; De Colibus, Luigi; Pardon, Els; Hannan, Saad; Scott, Suzanne; Sun, Zhaoyang; Frenz, Brandon; Klesse, Gianni; Li, Sai; M. Diprose, Jonathan; Alistair Siebert, C.; Esnouf, Robert; DiMaio, Frank; J. Tucker, Stephen; G. Smart, Trevor; Steyaert, Jan; Madan Babu, M.; S.P. Sansom, Mark; T. Huiskonen, Juha; Aricescu, A.R.

doi:10.1101/338343

Public

Heteromeric GABA A receptor structures in positively-modulated active states

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jun 4, 2018

Authors:

Paul S. Miller

Simonas Masiulis

Tomas Malinauskas

Abstract

Abstract Type-A γ-aminobutyric acid (GABA A ) receptors are pentameric ligand-gated ion channels (pLGICs), typically consisting of α/β/γ subunit combinations. They are the principal mediators of inhibitory neurotransmission throughout the central nervous system and targets of major clinical drugs, s...

Subject

Allosteric regulation

GABAA receptor

Inhibitory postsynaptic potential

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!