Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, Gail; Lam, Max; E. Harris, Sarah; W. Trampush, Joey; Luciano, Michelle; David Hill, W.; P. Hagenaars, Saskia; J. Ritchie, Stuart; E. Marioni, Riccardo; Fawns‐Ritchie, Chloe; C. Liewald, David; A. Okely, Judith; Ahola‐Olli, Ari; L. K. Barnes, Catriona; Bertram, Lars; C. Bis, Joshua; E. Burdick, Katherine; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; G. Giakoumaki, Stella; Giddaluru, Sudheer; E. Gustavson, Daniel; Hayward, Caroline; Hofer, Edith; Arfan Ikram, M.; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; A. Mather, Karen; Melle, Ingrid; W. Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; A. Reynolds, Chandra; Sargurupremraj, Muralidharan; Scholz, Markus; A. Smith, Jennifer; V. Smith, Albert; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; J. van der Lee, Sven; B. Ware, Erin; Gwen Windham, B.; J. Wright, Margaret; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; A. Andreassen, Ole; J. Armstrong, Nicola; A. Assareh, Amelia; Attia, John; K. Attix, Deborah; Avramopoulos, Dimitrios; A. Bennett, David; C. Böhmer, Anne; A. Boyle, Patricia; Brodaty, Henry; Campbell, Harry; D. Cannon, Tyrone; T. Cirulli, Elizabeth; Congdon, Eliza; Drabant Conley, Emily; Corley, Janie; R. Cox, Simon; M. Dale, Anders; Dehghan, Abbas; M. Dick, Danielle; Dickinson, Dwight; G. Eriksson, Johan; Εvangelou, Εvangelos; D. Faul, Jessica; Ford, Ian; B. Freimer, Nelson; Gao, He; Giegling, Ina; A. Gillespie, Nathan; D. Gordon, Scott; F. Gottesman, Rebecca; Griswold, Michael; Guðnason, Vilmundur; B. Harris, Tamara; M. Hartmann, Annette; Hatzimanolis, Alex; Heiss, Gerardo; G. Holliday, Elizabeth; K. Joshi, Peter; Kähönen, Mika; L. R. Kardia, Sharon; Karlsson, Ida; Kleineidam, Luca; S. Knopman, David; A. Kochan, Nicole; Konte, Bettina; B. Kwok, John; Le Hellard, Stéphanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu; M. Lill, Christina; Liu, Tian; Koini, Marisa; London, Edythe; T. Longstreth, W.; L. Lopez, Oscar; Loukola, Anu; Luck, Tobias; J. Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo‐Pekka; G. Martin, Nicholas; W. Montgomery, Grant; D. Murray, Alison; C. Need, Anna; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Goran; Pattie, Alison; Polašek, Ozren; A. Poldrack, Russell; M. Psaty, Bruce; Reppermund, Simone; G. Riedel‐Heller, Steffi; J. Rose, Richard; I. Rotter, Jerome; Roussos, Panos; P. Rovio, Suvi; Saba, Yasaman; W. Sabb, Fred; S. Sachdev, Perminder; L. Satizábal, Claudia; Schmid, Matthias; J. Scott, Rodney; A. Scult, Matthew; Simino, Jeannette; Eline Slagboom, P.; Smyrnis, Nikolaos; Soumaré, Aïcha; C. Stefanis, Nikos; J. Stott, David; E. Straub, Richard; Sundet, Kjetil; Taylor, Adele; D. Taylor, Kent; Tzoulaki, Ioanna; Tzourio, Christophe; G. Uitterlinden, André; Vitart, Véronique; N. Voineskos, Aristotle; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, Kexin; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; H.H. Adams, Hieab; E. Arking, Dan; M. Bilder, Robert; Bitsios, Panos; Boerwinkle, Eric; Chiba‐Falek, Ornit; Corvin, Aiden; L. De Jager, Philip; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; L. Fitzpatrick, Annette; Gill, Michael; C. Glahn, David; Hägg, Sara; K. Hansell, Narelle; R. Hariri, Ahmad; Kamran Ikram, M.; Wouter Jukema, J.; Vuoksimaa, Eero; C. Keller, Matthew; S. Kremen, William; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; L. Pedersen, Nancy; Pendleton, Neil; J. Porteous, David; Räikkönen, Katri; T. Raitakari, Olli; Ramı́rez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; W. Schofield, Peter; R. Schofield, Peter; M. Starr, John; M. Steen, Vidar; N. Trollor, Julian; T. Turner, Steven; M. van Duijn, Cornelia; Villringer, Arno; Weinberger, D.R.; R. Weir, David; F. Wilson, James; K. Malhotra, Anil; M. McIntosh, Andrew; R. Galé, Catharine; Seshadri, Sudha; H. Mosley, Thomas; Bressler, Jan; Lencz, Todd; J. Deary, Ian

doi:10.1038/s41467-018-04362-x

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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Published in Nature Communications • May 22, 2018

Authors:

Gail Davies

Max Lam

Sarah E. Harris

Abstract

Abstract General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant i...

Subject

Cognition

Function (biology)

Genetics

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