Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Meng, Jing; Chen, Shuang; Han, Jingxia; Qian, Baoxin; Wang, Xiaorui; Zhong, Weilong; Qin, Yuan; Zhang, Heng; Gao, Wan-Feng; Lei, Yue-Yang; Yang, Wei; Yang, Lan; Zhang, Chao; Liu, Huijuan; Liu, Yanrong; Zhou, Honggang; Sun, Tao; Yang, Cheng

doi:10.1158/0008-5472.can-17-3009

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Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Published in Cancer Research • May 29, 2018

Authors:

Jing Meng

Shuang Chen

Jingxia Han

Abstract

Abstract Twist is a critical epithelial–mesenchymal transition (EMT)–inducing transcription factor that increases expression of vimentin. How Twist1 regulates this expression remains unclear. Here, we report that Twist1 regulates Cullin2 (Cul2) circular RNA to increase expression of vimentin in EMT....

Subject

Hepatocellular carcinoma

Vimentin

Circular RNA

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