MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Promoda Perera, Agampodi; Fernando, Ruchira; Shinde, Tanvi; Gundamaraju, Rohit; Southam, Benjamin; Singh Sohal, Sukhwinder; A. B. Robertson, Avril; Schroder, Kate; Kunde, Dale; Eri, Rajaraman

doi:10.1038/s41598-018-26775-w

Public

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Published in Scientific Reports • May 30, 2018

Authors:

Agampodi Promoda Perera

Ruchira Fernando

Tanvi Shinde

Abstract

MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven inflammatory diseases. However, the effect of MCC950 on colonic inflammation has not yet been reported. In the present study we i...

Subject

Inflammasome

Inflammation

Colitis

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