Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Tiriac, Hervé; Belleau, Pascal; D. Engle, Dannielle; Plenker, Dennis; Deschênes, Astrid; D.D. Somerville, Tim; E. M. Froeling, Fieke; A. Burkhart, Richard; E. Denroche, Robert; Jang, Gun-Ho; Miyabayashi, Koji; Megan Young, C.; J. Patel, Hardik; Ma, Michelle; F. LaComb, Joseph; Lerie D. Palmaira, Randze; A. Javed, Ammar; C. Huynh, Jasmine; Johnson, Molly; Arora, Kanika; Robine, Nicolas; Shah, Minita; Sanghvi, Rashesh; Goetz, Austin; Y. Lowder, Cinthya; Martello, Laura; Driehuis, Else; Lecomte, Nicolas; Aşkan, Gökçe; A. Iacobuzio–Donahue, Christine; Clevers, Hans; D. Wood, Laura; H. Hruban, Ralph; D. Thompson, Elizabeth; J. Aguirre, Andrew; M. Wolpin, Brian; R. Sasson, Aaron; Kim, Joseph; Wu, Maoxin; Carlos Bucobo, Juan; J. Allen, Peter; V. Sejpal, Divyesh; H. Nealon, William; D. Sullivan, J.; M. Winter, Jordan; A. Gimotty, Phyllis; L. Grem, Jean; J. DiMaio, Dominick; M. Buscaglia, Jonathan; M. Grandgenett, Paul; R. Brody, Jonathan; A. Hollingsworth, Michael; M. O’Kane, Grainne; Notta, Faiyaz; Kim, Edward; M. Crawford, James; Devoe, Craig; J. Ocean, Allyson; L. Wolfgang, Christopher; H. Yu, Kenneth; Li, Ellen; R. Vakoc, Christopher; Hubert, Benjamin; E. Fischer, Sandra; M. Wilson, Julie; A. Moffitt, Richard; J. Knox, Jennifer; Krasnitz, Alexander; Gallinger, Steven; A. Tuveson, David

doi:10.1158/2159-8290.cd-18-0349

Public

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Published in Cancer Discovery • May 31, 2018

Authors:

Hervé Tiriac

Pascal Belleau

Dannielle D. Engle

Abstract

Abstract Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient–derived organoid (PDO) library that recapitulates the mutational spectrum and tr...

Subject

Pancreatic cancer

Medicine

Precision medicine

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