Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes

Liu, Wei; Wang, Yongxiang; Gong, Fangyi; Rong, Yuluo; Luo, Yongjun; Tang, Pengyu; Zhou, Zheng; Zhou, Zhimin; Xu, Tao; Jiang, Tao; Yang, Siting; Yin, Guoyong; Chen, Jian; Fan, Jin; Cai, Weihua

doi:10.1089/neu.2018.5835

Public

Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes

Published in Journal of Neurotrauma • May 31, 2018

Authors:

Wei Liu

Yongxiang Wang

Fangyi Gong

Abstract

Mesenchymal stem cell (MSC) transplantation is now considered as an effective treatment strategy for traumatic spinal cord injury (SCI). However, several key issues remain unresolved, including low survival rates, cell dedifferentiation, and tumor formation. Recent studies have demonstrated that the...

Subject

Mesenchymal stem cell

Paracrine signalling

Spinal cord injury

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