IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

Jo, Sungsin; Eun Wang, Sung; Lim Lee, Young; Kang, Suman; Lee, Bitnara; Han, Jinil; Sung, Il‐Hoon; Park, Ye‐Soo; Bae, Sang‐Cheol; Kim, Tae‐Hwan

doi:10.1186/s13075-018-1582-3

Public

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

Published in Arthritis Research & Therapy • Jun 7, 2018

Authors:

Sungsin Jo

Sung Eun Wang

Young Lim Lee

Abstract

BACKGROUND: IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony ankylosis. Here, we investigated the effects of anti IL-17A agents in AS. METHODS: ...

Subject

Osteoblast

Ankylosing spondylitis

Medicine

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