A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

Corpechot, Christophe; Chazouillères, Olivier; Rousseau, Alexandra; Le Gruyer, Antonia; Habersetzer, François; Mathurin, Philippe; Goria, Odile; Potier, Pascal; Minello, Anne; Silvain, Christine; Abergel, Armand; Debette‐Gratien, Maryline; Larrey, Dominique; Roux, Olivier; Bronowicki, Jean–Pierre; Boursier, Jérôme; de Lédinghen, Victor; Heurgué–Berlot, Alexandra; Nguyen-Khac, Éric; Zoulim, Fabien; Ollivier‐Hourmand, Isabelle; Zarski, Jean‐Pierre; Nkontchou, G.; Lemoinne, Sara; Humbert, Lydie; Rainteau, Dominique; Lefèvre, Guillaume; de Chaisemartin, Luc; Chollet‐Martin, Sylvie; Gaouar, Farid; Admane, Farid-Hakeem; Simon, Tabassome; Poupon, Raoul

doi:10.1056/nejmoa1714519

Public

A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

Published in New England Journal of Medicine • Jun 6, 2018

Authors:

Christophe Corpechot

Olivier Chazouillères

Alexandra Rousseau

Abstract

BACKGROUND: Patients with primary biliary cholangitis who have an inadequate response to therapy with ursodeoxycholic acid are at high risk for disease progression. Fibrates, which are agonists of peroxisome proliferator-activated receptors, in combination with ursodeoxycholic acid, have shown poten...

Subject

Bezafibrate

Ursodeoxycholic acid

Internal medicine

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