Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

Sridhar, Saranya; R. Luedtke, Alexander; Langevin, Edith; Zhu, Ming; Bonaparte, Matthew; Machabert, Tifany; J. Savarino, Stephen; Zambrano, Betzana; Moureau, Annick; Khromava, Alena; Moodie, Zoe; Westling, Ted; Mascareñas, César; Frago, Carina; Cortés, Margarita; Chansinghakul, Danaya; Noriega, Fernando; Bouckenooghe, Alain; Chen, Josh; Ng, Su-Peing; B. Gilbert, Peter; Gurunathan, Sanjay; A. DiazGranados, Carlos

doi:10.1056/nejmoa1800820

Public

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

Published in New England Journal of Medicine • Jun 13, 2018

Authors:

Saranya Sridhar

Alexander R. Luedtke

Edith Langevin

Abstract

BACKGROUND: In efficacy trials of a tetravalent dengue vaccine (CYD-TDV), excess hospitalizations for dengue were observed among vaccine recipients 2 to 5 years of age. Precise risk estimates according to observed dengue serostatus could not be ascertained because of the limited numbers of samples c...

Subject

Serostatus

Dengue fever

Dengue vaccine

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