YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

Ni, Xuhao; Tao, Jin‐Hui; Barbi, Joseph; Chen, Qian; V. Park, Benjamin; Li, Zhiguang; Zhang, Nailing; Lebid, Andriana; Ramaswamy, Anjali; Wei, Ping; Zheng, Ying; Zhang, Xuehong; Wu, Xingmei; Vignali, Paolo; Yang, Cuiping; Li, Huabin; M. Pardoll, Drew; Lu, Ling; Pan, Duojia; Pan, Fan

doi:10.1158/2159-8290.cd-17-1124

Public

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

Published in Cancer Discovery • Jun 15, 2018

Authors:

Xuhao Ni

Jin‐Hui Tao

Joseph Barbi

Abstract

Abstract Regulatory T cells (Treg) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective antitumor immune responses. FOXP3 is a transcription factor expressed in Tregs that is required for their function. However, the pathways and mic...

Subject

Immunity

Treg cell

Immunology

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