DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Yurevna Zheleznyakova, Galina; Marabita, Francesco; Gómez-Cabrero, David; James, Tojo; Ewing, Ewoud; Lindén, Magdalena; Górnikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; F. M. Andlauer, Till; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Björn; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann‐Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Oliver Schmidt, Carsten; Kacprowski, Tim; Franke, André; Laudes, Matthias; Dilthey, Alexander; Gulowsen Celius, Elisabeth; Bach Søndergaard, Helle; Tegnér, Jesper; F. Harbo, Hanne; Oturai, Annette; Ólafsson, Sigurgeir; P. Eggertsson, Hannes; V. Halldórsson, Bjarni; Hjaltason, Haukur; Ólafsson, Elías; Jónsdóttir, Ingileif; Stefánsson, Kāri; Olsson, Tomas; Piehl, Fredrik; J. Ekström, Tomas; Kockum, Ingrid; P. Feinberg, Andrew; Jagodic, Maja

doi:10.1038/s41467-018-04732-5

Public

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Published in Nature Communications • Jun 13, 2018

Authors:

Lara Kular

Yun Liu

Sabrina Ruhrmann

Abstract

Abstract The human leukocyte antigen (HLA) haplotype DRB1*15 : 01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15 : 01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15 : 01 . A differentially methylated region (DMR) encompassing HL...

Subject

Mediator

DNA methylation

Multiple sclerosis

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