DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Sasidharan Nair, Varun; El Salhat, Haytham; Z. Taha, Rowaida; John, Anne; R. Ali, Bassam; Elkord, Eyad

doi:10.1186/s13148-018-0512-1

Public

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Published in Clinical Epigenetics • Jun 15, 2018

Authors:

Varun Sasidharan Nair

Haytham El Salhat

Rowaida Z. Taha

Abstract

Background: High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune ch...

Subject

TIGIT

DNA methylation

Gene

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