Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

H. Kugel, Curtis; M. Douglass, Stephen; R. Webster, Marie; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; A. Weiss, Sarah; Darvishian, Farbod; N. Al-Rohil, Rami; Ndoye, Abibatou; Behera, Reeti; M. Alicea, Gretchen; L. Ecker, Brett; Fane, Mitchell; J. Allegrezza, Michael; Svoronos, Nikolaos; Kumar, Vinit; Y. Wang, Daniel; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; R. Conejo-Garcia, Jose; Gabrilovich, Dmitry; L. Stone, Erica; S. Nowicki, Theodore; Sosman, Jeffrey; Rai, Rajat; S. Carlino, Matteo; V. Long, Georgina; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; A. Davies, Michael; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; K. Amaravadi, Ravi; M. Menzies, Alexander; L. McQuade, Jennifer; B. Johnson, Douglas; Osman, Iman; T. Weeraratna, Ashani

doi:10.1158/1078-0432.ccr-18-1116

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Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

Shared by NobleBlocks on Nov 1, 2018 • 12:00 AM UTC

Authors:

Curtis H. Kugel

Stephen M. Douglass

Marie R. Webster

Abstract

Abstract Purpose: We have shown that the aged microenvironment increases melanoma metastasis, and decreases response to targeted therapy, and here we queried response to anti-PD1. Experimental Design: We analyzed the relationship between age, response to anti-PD1, and prior therapy in 538 patients. ...

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