Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

Lin, Haizhou; Lyu, Haining; Zhou, Shuang; Yu, Jingwen; P. Keller, Nancy; Chen, Lin; Yin, Wen‐Bing

doi:10.1039/c8ob01326h

Public

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

Published in Organic & Biomolecular Chemistry • Jan 1, 2018

Authors:

Haizhou Lin

Haining Lyu

Shuang Zhou

Abstract

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the...

Subject

Aspergillus nidulans

Chemistry

Regulator

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