Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

He, Hongbin; Jiang, Hua; Chen, Yun; Ye, Jin; Wang, Aoli; Wang, Chao; Liu, Qingsong; Liang, Gaolin; Deng, Xianming; Jiang, Wei; Zhou, Rongbin

doi:10.1038/s41467-018-04947-6

Public

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Published in Nature Communications • Jun 25, 2018

Authors:

Hongbin He

Hua Jiang

Yun Chen

Abstract

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-dri...

Subject

Inflammasome

Pyrin domain

Covalent bond

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!