Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice

Fan, Xuemei; Wang, Conghui; Shi, Panlai; Gao, Wen; Gu, Jianmin; Geng, Yan; Yang, Wenlong; Wu, Ningbo; Wang, Yang; Xu, Yanyan; Chen, Xue; Zhang, Lin; Wang, Kemin; Su, Bing; Liu, Junling

doi:10.1182/bloodadvances.2017015149

Public

Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice

Published in Blood Advances • Jun 25, 2018

Authors:

Xuemei Fan

Conghui Wang

Panlai Shi

Abstract

mice had fewer microthrombi, reduced myocardial infarction (MI) size, and improved post-MI heart function in a mouse model of MI. These results suggest that MEKK3 plays important roles in platelet MAPK activation and may be used as a new effective target for antithrombosis and prevention of MI expan...

Subject

Thrombosis

Myocardial infarction

Cardiology

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