Duplex signaling by CaM and Stac3 enhances Ca<sub>V</sub>1.1 function and provides insights into congenital myopathy.

J, Niu; W, Yang; DT, Yue; T, Inoue; M, Ben-Johny

doi:10.1085/jgp.201812005

Public

Duplex signaling by CaM and Stac3 enhances CaV1.1 function and provides insights into congenital myopathy.

Shared by NobleBlocks on Jun 27, 2018 • 12:00 AM UTC

Authors:

Niu J

Yang W

Yue DT

Abstract

CaV1.1 is essential for skeletal muscle excitation-contraction coupling. Its functional expression is tuned by numerous regulatory proteins, yet underlying modulatory mechanisms remain ambiguous as CaV1.1 fails to function in heterologous systems. In this study, by dissecting channel trafficking ver...

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