Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

Lively, Starlee; C. Schlichter, Lyanne

doi:10.3389/fncel.2018.00215

Public

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

Published in Frontiers in Cellular Neuroscience • Jul 24, 2018

Authors:

Starlee Lively

Lyanne C. Schlichter

Abstract

Microglia respond to CNS injuries and diseases with complex reactions, often called ‘activation’. A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations for this study. First, bacterial endotoxin (lipopolys...

Subject

Microglia

Tumor necrosis factor alpha

Immunology

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