Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

G. Jones, Mark; G. Andriotis, Orestis; Roberts, James; Lunn, Kerry; Tear, Victoria; Cao, Lucy; Ask, Kjetil; E. Smart, David; Bonfanti, Alessandra; Johnson, Peter; Alzetani, Aiman; Conforti, Franco; Doherty, Regan; Lai, Chester; C. Johnson, Benjamin; N. Bourdakos, Konstantinos; Fletcher, Sophie; G. Marshall, Ben; Jogai, Sanjay; J. Brereton, Christopher; Chee, Serena; H. Ottensmeier, Christian; J. Sime, Patricia; Gauldie, Jack; Kolb, Martin; Mahajan, Sumeet; Fabre, Aurélie; Bhaskar, Atul; Jarolimek, Wolfgang; Richeldi, Luca; Ma O’Reilly, Katherine; Monk, Phillip; J. Thurner, Philipp; E. Davies, Donna

doi:10.7554/elife.36354

Public

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Published in eLife • Jul 2, 2018

Authors:

Mark G. Jones

Orestis G. Andriotis

James Roberts

Abstract

Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in human disease. By integrated multiscale biomechanical...

Subject

Extracellular matrix

Fibrosis

Homeostasis

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