MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

Watanabe, Ryu; Maeda, Toshihisa; Zhang, Hui; J. Berry, Gerald; Zeisbrich, Markus; Brockett, Robert; E. Greenstein, Andrew; Tian, Lü; J. Goronzy, Jörg; M. Weyand, Cornelia

doi:10.1161/circresaha.118.313206

Public

MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

Published in Circulation Research • Jul 3, 2018

Authors:

Ryu Watanabe

Toshihisa Maeda

Hui Zhang

Abstract

Rationale: Giant cell arteritis (GCA)—a primary vasculitis of medium and large arteries—is associated with vessel wall damage, elastic membrane fragmentation, and vascular remodeling. Proteinases are believed to contribute to pathogenesis by degrading extracellular matrix and causing tissue injury. ...

Subject

Matrix metalloproteinase

Pathology

Biology

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