Age-related shift in LTD is dependent on neuronal adenosine A<sub>2A</sub> receptors interplay with mGluR5 and NMDA receptors.

M, Temido-Ferreira; DG, Ferreira; VL, Batalha; I, Marques-Morgado; JE, Coelho; P, Pereira; R, Gomes; A, Pinto; S, Carvalho; PM, Canas; L, Cuvelier; V, Buée-Scherrer; E, Faivre; Y, Baqi; CE, Müller; J, Pimentel; SN, Schiffmann; L, Buée; M, Bader; TF, Outeiro; D, Blum; RA, Cunha; H, Marie; PA, Pousinha; LV, Lopes

doi:10.1038/s41380-018-0110-9

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Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Shared by NobleBlocks on Jun 27, 2018 • 12:00 AM UTC

Authors:

Temido-Ferreira M

Ferreira DG

Batalha VL

Abstract

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the ...

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