Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

Sin Oh, Yoon; Deuk Bae, Gong; Jae Baek, Dong; Park, Eun‐Young; Jun, Hee‐Sook

doi:10.3389/fendo.2018.00384

Public

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

Published in Frontiers in Endocrinology • Jul 16, 2018

Authors:

Yoon Sin Oh

Gong Deuk Bae

Dong Jae Baek

Abstract

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturba...

Subject

Lipotoxicity

Insulin resistance

Type 2 diabetes

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