A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.

KI, López-Cayuqueo; M, Chavez-Canales; A, Pillot; P, Houillier; M, Jayat; J, Baraka-Vidot; F, Trepiccione; V, Baudrie; C, Büsst; C, Soukaseum; Y, Kumai; X, Jeunemaître; J, Hadchouel; D, Eladari; R, Chambrey

doi:10.1016/j.kint.2018.05.001

Public

A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.

Shared by NobleBlocks on Jul 7, 2018 • 12:00 AM UTC

Authors:

López-Cayuqueo KI

Chavez-Canales M

Pillot A

Abstract

Pseudohypoaldosteronism type II (PHAII) is a genetic disease characterized by association of hyperkalemia, hyperchloremic metabolic acidosis, hypertension, low renin, and high sensitivity to thiazide diuretics. It is caused by mutations in the WNK1, WNK4, KLHL3 or CUL3 gene. There is strong evidence...

Subject

Hypertension

Renal tubular acidosis

Pendrin

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