Scleral hypoxia is a target for myopia control

Wu, Hao; Chen, Wei; Zhao, Fei; Zhou, Qingyi; S. Reinach, Peter; Deng, Lili; Ma, Li; Luo, Shumeng; Srinivasalu, Nethrajeith; Pan, Miaozhen; Hu, Yang; Pei, Xiaomeng; Sun, Jing; Ren, Ran; Xiong, Yinghui; Zhou, Zhonglou; Zhang, Sen; Tian, Geng; Fang, Jianhuo; Zhang, Lina; Lang, Jidong; Wu, Deng; Zeng, Changqing; Qu, Jia; Zhou, Xiangtian

doi:10.1073/pnas.1721443115

Public

Scleral hypoxia is a target for myopia control

Published in Proceedings of the National Academy of Sciences • Jul 9, 2018

Authors:

Hao Wu

Wei Chen

Fei Zhao

Abstract

) promoted myofibroblast transdifferentiation with down-regulation of type I collagen in human scleral fibroblasts. Importantly, the antihypoxia drugs salidroside and formononetin down-regulated HIF-1α expression as well as the phosphorylation levels of eIF2α and mTOR, slowing experimental myopia pr...

Subject

Hypoxia (environmental)

Ophthalmology

Optometry

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