Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

Xing, Fei; Liu, Yin; Wu, Shih-Ying; Wu, Kerui; Sharma, Sambad; Mo, Yin‐Yuan; Feng, Jiamei; Sanders, Stephanie; Jin, Guangxu; Singh, Ravi; Vidi, Pierre‐Alexandre; Tyagi, Abhishek; D. Chan, Michael; Ruiz, Jimmy; Debinski, Waldemar; Pasche, Boris; Lo, Hui‐Wen; J. Metheny‐Barlow, Linda; B. D’Agostino, Ralph; Watabe, Kounosuke

doi:10.1158/0008-5472.can-18-1102

Public

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

Published in Cancer Research • Jul 19, 2018

Authors:

Fei Xing

Yin Liu

Shih-Ying Wu

Abstract

Abstract Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet the pathologic mechanism behind this development remains poorly understood. Here, we profiled long noncoding RNAs in brain metastatic tumors from patients with breast cancer and found that the X-ina...

Subject

XIST

Cancer research

Metastasis

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