Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial

J. Nicholls, Stephen; Andrews, Jordan; J.P. Kastelein, John; Merkely, Béla; E. Nissen, Steven; K. Ray, Kausik; G. Schwartz, Gregory; G. Worthley, Stephen; Keyserling, Connie; Dasseux, Jean‐Louis; Griffith, Liddy; Kim, Susan; Janssan, A.; Di Giovanni, Giuseppe; D. Pisaniello, Anthony; Scherer, D.; J. Psaltis, Peter; Butters, Julie

doi:10.1001/jamacardio.2018.2121

Public

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial

Published in JAMA Cardiology • Jul 25, 2018

Authors:

Stephen J. Nicholls

Jordan Andrews

John J.P. Kastelein

Abstract

Importance: CER-001 is a negatively charged, engineered pre-β high-density lipoprotein (HDL) mimetic containing apolipoprotein A-I and sphingomyelin. Preliminary studies demonstrated favorable effects of CER-001 on cholesterol efflux and vascular inflammation. A post hoc reanalysis of a previously c...

Subject

Medicine

Acute coronary syndrome

Internal medicine

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