Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Xue, Angli; Wu, Yang; Zhu, Zhihong; Zhang, Futao; E. Kemper, Kathryn; Zheng, Zhili; Yengo, Loïc; R. Lloyd‐Jones, Luke; Sidorenko, Julia; Wu, Yeda; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Kumar Andiappan, Anand; Awadalla, Philip; Battle, Alexis; Beutner, Frank; Jan Bonder, Marc; I. Boomsma, Dorret; Christiansen, Mark; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; M. Frayling, Timothy; A. Gharib, Sina; Gibson, Gregory; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johannes; Kim, Yungil; Kirsten, Holger; Kovács, Péter; Krohn, Knut; Kronberg-Guzman, Jaanika; Kukushkina, Viktorija; Kutalik, Zoltán; Lee, Bernett; Lehtimäki, Terho; Loeffler, Markus; M. Marigorta, Urko; Metspalu, Andres; Milani, Lili; Müller‐Nurasyid, Martina; Nauck, Matthias; G. Nivard, Michel; W.J.H. Penninx, Brenda; Perola, Markus; Pervjakova, Natalia; L. Pierce, Brandon; E. Powell, Joseph; Prokisch, Holger; M. Psaty, Bruce; T. Raitakari, Olli; M. Ring, Susan; Ripatti, Samuli; Rötzschke, Olaf; Rüeger, Sina; Saha, Ashis; Scholz, Markus; Schramm, Katharina; Seppälä, Ilkka; Stümvoll, Michael; Sullivan, Patrick; Teumer, Alexander; Thiery, Joachim; Lin, Tong; Tönjes, Anke; van Dongen, Jenny; B. J. van Meurs, Joyce; Verlouw, Joost; Völker, Uwe; Võsa, Urmo; Yaghootkar, Hanieh; Zeng, Biao; F. McRae, Allan; M. Visscher, Peter; Zeng, Jian; Yang, Jian

doi:10.1038/s41467-018-04951-w

Public

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Published in Nature Communications • Jul 23, 2018

Authors:

Angli Xue

Yang Wu

Zhihong Zhu

Abstract

Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of w...

Subject

Genome-wide association study

Biology

Epigenomics

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