CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Chen, Limo; Diao, Lixia; Yang, Yongbin; Yi, Xiaohui; Leticia Rodriguez, B.; Li, Yanli; Villalobos, Pamela; Cascone, Tina; Liu, Xi; Tan, Lin; L. Lorenzi, Philip; Huang, Anfei; Zhao, Qiang; Peng, Di; J. Fradette, Jared; H. Peng, David; Ungewiss, Christin; D. Roybal, Jonathon; Tong, Pan; Oba, Junna; Skoulidis, Ferdinandos; Peng, Weiyi; W. Carter, Brett; M. Gay, Carl; Fan, You-Hong; A. Class, Caleb; Zhu, Jingfen; Rodriguez‐Canales, Jaime; Kawakami, Masanori; A. Byers, Lauren; E. Woodman, Scott; A. Papadimitrakopoulou, Vassiliki; Dmitrovsky, Ethan; Wang, Jing; E. Ullrich, Stephen; I. Wistuba, Ignacio; V. Heymach, John; Xiao‐Feng Qin, F.; L. Gibbons, Don

doi:10.1158/2159-8290.cd-17-1033

Public

CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Published in Cancer Discovery • Jul 16, 2018

Authors:

Limo Chen

Lixia Diao

Yongbin Yang

Abstract

Abstract Although treatment with immune checkpoint inhibitors provides promising benefit for patients with cancer, optimal use is encumbered by high resistance rates and requires a thorough understanding of resistance mechanisms. We observed that tumors treated with PD-1/PD-L1 blocking antibodies de...

Subject

Immunosuppression

Blockade

PD-L1

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